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Advanced Growth Factor Serum 1 fl. oz (30 ml)

Advanced Growth Factor Serum 1 fl. oz (30 ml)

Regular price $65.00 Sale

Youthful skin reflects the inner workings of growth factors that drive tissue function and regeneration in response to both internal and external factors.1 The decreased concentrations of four key growth factors as we grow older inhibit the skin matrix and lead to the tell-tale signs of normal aging. Replenishing these growth factors restores the skin's natural rejuvenation process.2 Research shows that when topically applied as a serum, these growth factors support the appearance of firmer, younger skin.

  • Epidermal growth factor (EGF): sh-Oligopeptide-1 supports the proliferation of epithelial cells to promote skin health and activates hyaluronan synthase 2—an enzyme involved in manufacturing hyaluronic acid that restores skin hydration.3
  • Insulin-like growth factor-1 (IGF-1): sh-Oligopeptide-2 supports the proliferation of fibroblasts that synthesize skin matrix components including collagen, elastin, and hyaluronic acid.4
  • Vascular endothelial growth factor (VEGF): sh-Polypeptide-9 supports the formation of new blood vessels (angiogenesis) and vascular permeability to allow a greater delivery of oxygen and nutrients into the extracellular matrix to facilitate function.5
  • Fibroblast growth factor (FGF): sh-Polypeptide-1 and sh-Polypeptide-11 support the production of collagen and elastin that gives skin its tensile strength and elasticity.6 It also supports skin matrix rejuvenation.


  1. Martin P. Science. 1997 Apr;276(5309):75-81.
  2. Fabi S. Facial Plast Surg. 2014;30:157-171.
  3. Pienimaki JP et al. J Biol Chem. 2001 Jun;276(23):20428-35.
  4. Gartner MH et al. J Surg Res. 1992 Apr;52(4):389-94.
  5. Ferrara N. Am J Physiol Cell Physiol. 2001 Jun;280(6):C1358-66.
  6. Takehara K. J Dermatol Sci. 2000 Dec;24 Suppl 1:S70-7.
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